|
Duncan AW, Rattis FM, Dimascio LN, Congdon KL, Pazianos G, Zhao C, Yoon K, Cook JM, Willert K, Gaiano N, Reya T. (2005) Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nature Immunology, 6(3):314-22.
Supplementary Fig. 1 (pdf 116K)
GFP protein expression reflects active Notch signaline in TNR hematopoietic cells.
Supplementary Fig. 2 (pdf 200K)
Control staining for cKti and of bone sections from WT mice.
Supplementary Fig. 3 (pdf 636K)
Analysis of Notch reporter activity in lineage positive cells.
Supplementary Fig. 4 (pdf 252K)
Pattern of Notch signaling activation in subpopulations of CD4-CD8- double negative thymocytes.
Supplementary Fig. 5 (pdf 60K)
Analysis of individual lineage markers on in vitro differentiated KLS GFP+ cells.
Supplementary Fig. 6 (pdf 144K)
Expression of dnXSu(H) in virally-transduced HSCs.
Supplementary Fig. 7 (pdf 84K)
Lineage markers are equivalently expressed in uninfected KTLS cells transduced with control or dnXSu(H) retroviruses.
Supplementary Fig. 8 (pdf 232K)
Inhibition of Notch signaling in vivo leads to an increase in myeloid and B lineage cells and to vector silencing in double negative thymocytes in vivo.
Supplementary Methods (pdf 52K)
|